Quick Answer: What Inhibits Osteoclast Activity?

What hormones affect osteoclast and osteoblast activity?

Estrogen acts on both osteoclasts and osteoblasts to inhibit bone breakdown at all stages in life.

Estrogen may also stimulate bone formation..

Does estrogen increase bone density?

Estrogen is a sex hormone that is essential to female bone health because it promotes the activity of osteoblasts, which are cells that produce bone. When estrogen levels drop during menopause, the osteoblasts aren’t able to effectively produce bone.

What hormone inhibits osteoclast activity?

calcitoninOf the two best known hormonal inhibitors of bone resorption in vivo, calcitonin acts directly upon osteoclasts to inhibit their activity, whereas estrogen acts indirectly, via the regulation of several cytokines.

What are osteoclasts inhibited by?

osteoprotegerinOsteoclast differentiation is inhibited by osteoprotegerin (OPG), which is produced by osteoblasts and binds to RANKL thereby preventing interaction with RANK. It may be important to note that while osteoclasts are derived from the hematopoietic lineage, osteoblasts are derived from mesenchymal stem cells.

Does estrogen inhibit osteoclast activity?

The main effect of estrogen is to inhibit bone remodeling, likely via the osteocyte. Estrogen also inhibits bone resorption, principally by directs effects on osteoclasts, although effects of estrogen on osteoblast/osteocyte and T-cell regulation of osteoclasts likely also play a role.

What does osteoclast activity do?

Osteoclastic activity refers to the body’s process of breaking down bone in order to build it up again. When consistent force is applied to a tooth, osteoclastic activity breaks down the bone in the jaw, allowing the tooth to move.