What Organs Are Affected By Osteogenesis Imperfecta?

Who is most affected by osteogenesis imperfecta?

OI occurs in approximately 1 in 20,000 individuals, including people diagnosed after birth.

OI occurs with equal frequency among males and females and among racial and ethnic groups.

Life expectancy varies depending on how severe the OI is, ranging from very brief (lethal form, OI type II) to average..

What disease does Byron Baxter have?

That’s because Byron is living with a brittle bone disease, a rare genetic condition with no cure. Doctors call it osteogenesis imperfecta, which means “imperfectly formed bone.”

What organs are affected by brittle bone disease?

Pulmonary: In people with severe forms of OI, respiratory complications are a leading cause of death. Although respiratory problems are usually more severe in those with severe OI, the primary collagen defect affects lung tissue in all people with OI, including those with a mild phenotype.

What population is affected by osteogenesis imperfecta?

Osteogenesis imperfecta affects approximately 1 in 10,000 to 20,000 people worldwide. An estimated 25,000 to 50,000 people in the United States have the condition.

How does brittle bone disease affect you physically?

There is no cure for brittle bone disease, but treatment can relieve symptoms, prevent breakage of bones, and maximize movement. Severe forms of the disease can affect the shape of the rib cage and spine, which can lead to life-threatening breathing problems. Some people may need to be on oxygen.

Does osteogenesis imperfecta affect lifespan?

Most children born with type I OI live normal, healthy lives into adulthood. Less severe symptoms do not affect life expectancy. Most OI-related deaths result from respiratory failure due to weak lungs. The most severe types will result in death at birth or soon after.

Is Oi a disability?

Most people with OI experience physical disability. OI also can cause weak muscles, brittle teeth, a curved spine, and hearing loss. Most forms of OI are caused by abnormal genes that are passed down from one or both parents to their children. There are currently 11 types of OI.

Is Osteogenesis Imperfecta a type of dwarfism?

Osteogenesis imperfecta (OI) Type III is a dwarfism condition, with adults generally reaching a height of three feet, although profound short stature is often associated with the other three types as well.

What is the cause of OI?

What causes osteogenesis imperfecta (OI)? OI is caused by defects in or related to a protein called type 1 collagen (pronounced KOL-uh-juhn). Collagen is an essential building block of the body. The body uses type 1 collagen to make bones strong and to build tendons, ligaments, teeth, and the whites of the eyes.

Are you born with osteogenesis imperfecta?

Osteogenesis imperfecta (OI) is an inherited (genetic) bone disorder that is present at birth.

How long do people live with brittle bone?

The prognosis for infants with the most severe form of osteogenesis imperfecta is poor, and most children may not live beyond a few weeks. The prognosis for those with milder forms of the condition who receive good medical management is much better, and many people may have average lifespans.

Does brittle bone disease affect teeth?

Osteogenesis Imperfecta (OI) is always associated with bone fragility. In addition, OI may affect the growth of the jaws and may or may not affect the teeth. About half of the people who have OI have teeth that appear normal, and their major concerns are routine care.

Is Osteogenesis Imperfecta painful?

Conclusions: Pain is a common occurrence for children with OI and is both acute and chronic in nature, interfering with children’s daily living activities. OI pain may not be optimally treated because many children experienced moderate to severe pain despite use of analgesics and/or coping strategies.

Where is osteogenesis imperfecta most common?

Four main types of OI have been identified. OI type I is the most common and the mildest form of the disorder. OI type II is the most severe. In most cases, the various forms of osteogenesis imperfecta are inherited as autosomal dominant traits.

How many babies are born with osteogenesis imperfecta?

OI can sometimes be life-threatening if it occurs in babies either before or shortly after birth. Approximately one person in 20,000 will develop brittle bone disease.